2,4-二氟-3-甲酰基苯甲腈合成路线 （共 3 条）
反应条件
lithium diisopropyl amide 1.) THF, -75 deg C, 15 min, 2.) THF; Multistep reaction;
参考文献
Eisai Co., Ltd.
Patent: EP1380576 A1, 2004 ;
Location in patent: Page 104 ;
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=0°C; 0.333333 h; 2: 2,4-difluoro-benzonitrile in tetrahydrofuran; hexane T=-78°C; 0.166667 h; 3: N,N-dimethyl-formamide With acetic acid more than 3 stages;
参考文献
Eisai Co., Ltd.
Patent: EP1510516 A1, 2005 ;
Location in patent: Page/Page column 85 ;
反应条件
hydrazine in tetrahydrofuran; methanol T=20 - 70°C; 78 h;
参考文献
EP1510516 A1, ;
Page/Page column 85-86 ;
