1-(3,5-二甲氧基苯基)乙醇合成路线 （共 16 条）
反应条件
1: LiAlH4, (-)-trans-2-ethyl-4-hydroxymethyl-5-phenyloxazoline 2: pyridine 3: 33 percent Chromat. / methanol; H2O / 2.5 h / Ambient temperature; Irradiation View Scheme
参考文献
DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.
Patent: WO2005/123724 A1, 2005 ;
Location in patent: Page/Page column 51 ;
反应条件
potassium in tetrahydrofuran T=45°C; 24 h;
参考文献
Azzena, Ugo; Melloni, Giovanni; Piroddi, Anna Maria; Azara, Emanuela; Contini, Stefania; Fenude, Emma
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3101 - 3106
反应条件
in diethyl ether 2 h; Ambient temperature;
参考文献
Cristol, Stanley J.; Ali, Mahfuza B.; Sankar, Iyer V.
Journal of the American Chemical Society, 1989 , vol. 111, # 21 p. 8207 - 8211
反应条件
1: methyl iodide With magnesium in diethyl ether 2: 3,5-dimethoxy-benzaldehyde in diethyl ether Grignard reaction;
参考文献
Roberts, Jeffrey C.; Pincock, James A.
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1480 - 1492
反应条件
1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux 2: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight 3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight 2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: With sodium in tetrahydrofuran T=20°C; 16 h; 2: With water in tetrahydrofuran T=20°C; Further stages.;
参考文献
Azzena, Ugo; Dettori, Giovanna; Mascia, Ilaria; Pisano, Luisa; Pittalis, Mario
Tetrahedron, 2007 , vol. 63, # 48 p. 11998 - 12006
反应条件
magnesium; methyl iodide in diethyl ether 1.) 3 h, reflux; 2.) 1 h, reflux; Yield given;
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: pyridine 2: 33 percent Chromat. / methanol; H2O / 2.5 h / Ambient temperature; Irradiation View Scheme
参考文献
Jaeger, David A.; Angelos, George H.
Tetrahedron Letters, 1981 , vol. 22, p. 803 - 806
反应条件
in methanol; water 2.5 h; Ambient temperatureIrradiation; Further byproducts given;
参考文献
Jaeger, David A.; Angelos, George H.
Tetrahedron Letters, 1981 , vol. 22, p. 803 - 806
