4-(1,4-二氧杂螺[4.5]癸-8-基)苯甲腈合成路线 （共 4 条）
反应条件
toluene-4-sulfonic acid 2 h; Reflux;
参考文献
RESPIRATORIUS AB
Patent: US2012/40942 A1, 2012 ;
Location in patent: Page/Page column 59-60 ;
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 3 h / 0 - 20 °C 1.2: 0 °C / pH 10 2.1: pivaloyl chloride; pyridine / dichloromethane / 20 °C 3.1: toluene-4-sulfonic acid / 2 h / Reflux View Scheme
参考文献
RESPIRATORIUS AB
Patent: US2012/40942 A1, 2012 ;
反应条件
1: pivaloyl chloride; pyridine / dichloromethane / 20 °C 2: toluene-4-sulfonic acid / 2 h / Reflux View Scheme
参考文献
RESPIRATORIUS AB
Patent: US2012/40942 A1, 2012 ;
反应条件
in tert-butyl methyl ether; water; ethyl acetate; acetone
参考文献
Karl Thomae GmbH
Patent: US5541343 A1, 1996 ;
