(R)-3-(3-氟苯基)-5-羟甲基恶唑烷-2-酮合成路线 （共 13 条）
反应条件
1: triethylamine / dichloromethane 2: sodium azide / N,N-dimethyl-formamide / 70 °C View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: triethylamine / dichloromethane
2: sodium azide / N,N-dimethyl-formamide / 70 °C
3: triphenylphosphine / tetrahydrofuran; water / 50 °C
4: triethylamine / dichloromethane / 0 - 20 °C
5: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
iodide; silver trifluoroacetate in acetonitrile
T=20°C; 24 h;
参考文献
DONG-A PHARM.CO.,LTD.
Patent: WO2005/58886 A1, 2005 ;
Location in patent: Page/Page column 24; 25 ;
