(S)-N-[3-(3-氟-4-碘-苯基)-2-氧代-唑烷-5-甲基]-乙酰氨合成路线 （共 12 条）
反应条件
hexamethyl-distannane in 1,4-dioxane; dichloro bis(triphenylphosphine)palladium (II)
参考文献
Lee, Jae-Gul; Leem, Won-Bin; Cho, Jong-Hwan; Choi, Sung-Hak; Lee, Jong-Jin; Park, Sang-Kuk; Lee, Tae-Hoo; Kim, Dong-Goo; Sung, Hyun-Jung
Patent: US2003/166620 A1, 2003 ;
反应条件
1: (5S)-5-(aminomethyl)-3-(3-fluoro-4-iodophenyl)-1,3-oxazolidin-2-on With triethylamine in dichloromethane
T=25°C;
2: acetic anhydride With 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=0 - 5°C; 2 h; Inert atmosphere;
参考文献
Chen, Shili; Lou, Rongliang; Wu, Yusheng; Zhou, Jiacheng; Hanselmann, Roger
Patent: US2010/234615 A1, 2010 ;
Location in patent: Page/Page column 37-38 ;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/56817 A1, 2004 ;
Location in patent: Page 89 ;
WO 2004/056817 A1
反应条件
1: sodium azide / N,N-dimethyl-formamide / 70 °C
2: triphenylphosphine / tetrahydrofuran; water / 50 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: triphenylphosphine / tetrahydrofuran; water / 50 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: sodium hydrogencarbonate / water; acetone / 0 °C
2: n-butyllithium / tetrahydrofuran / -78 - 20 °C
3: triethylamine / dichloromethane
4: sodium azide / N,N-dimethyl-formamide / 70 °C
5: triphenylphosphine / tetrahydrofuran; water / 50 °C
6: triethylamine / dichloromethane / 0 - 20 °C
7: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran
2: sodium hydrogencarbonate / water; acetone / 0 °C
3: n-butyllithium / tetrahydrofuran / -78 - 20 °C
4: triethylamine / dichloromethane
5: sodium azide / N,N-dimethyl-formamide / 70 °C
6: triphenylphosphine / tetrahydrofuran; water / 50 °C
7: triethylamine / dichloromethane / 0 - 20 °C
8: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
iodine; silver trifluoroacetate in chloroform; acetonitrile
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: n-butyllithium / tetrahydrofuran / -78 - 20 °C
2: triethylamine / dichloromethane
3: sodium azide / N,N-dimethyl-formamide / 70 °C
4: triphenylphosphine / tetrahydrofuran; water / 50 °C
5: triethylamine / dichloromethane / 0 - 20 °C
6: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
