(S)-N-[3-(3-氟-4-碘-苯基)-2-氧代-唑烷-5-甲基]-乙酰氨合成路线 （共 12 条）
反应条件
1: triethylamine / dichloromethane
2: sodium azide / N,N-dimethyl-formamide / 70 °C
3: triphenylphosphine / tetrahydrofuran; water / 50 °C
4: triethylamine / dichloromethane / 0 - 20 °C
5: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
hydrogenchloride; water in methanol
T=65°C; 120 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/56819 A1, 2004 ;
Location in patent: Page 54 ;
WO 2004/056819 A1
