(3-氟苯基)氨基甲酸苄酯合成路线 （共 9 条）
反应条件
sodium hydrogencarbonate in tetrahydrofuran T=0°C; 2 h;
参考文献
DONG-A PHARM.CO.,LTD.
Patent: WO2005/58886 A1, 2005 ;
Location in patent: Page/Page column 23; 24 ;
反应条件
1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran 2: sodium hydrogencarbonate / water; acetone / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5266 - 5269
反应条件
1: N-(carbobenzyloxy)-3-fluoroaniline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.75 h; 2: (S)-(+)-butyric acid oxiranylmethyl ester in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Ali, Akbar; Reddy, G. S. Kiran Kumar; Nalam, Madhavi N. L.; Anjum, Saima Ghafoor; Cao, Hong; Schiffer, Celia A.; Rana, Tariq M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7699 - 7708
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 deg C -> room temperature View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: n-butyllithium / tetrahydrofuran / -78 - 20 °C 2: triethylamine / dichloromethane 3: sodium azide / N,N-dimethyl-formamide / 70 °C View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1: N-(carbobenzyloxy)-3-fluoroaniline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.166667 h; Inert atmosphere; 2: (-)-(R)-glycidyl butyrate in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere;
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
反应条件
in tetrahydrofuran; methanol
参考文献
The Upjohn Company
Patent: US5565571 A1, 1996 ;
反应条件
1: n-butyllithium / tetrahydrofuran / -78 - 20 °C
2: triethylamine / dichloromethane
3: sodium azide / N,N-dimethyl-formamide / 70 °C
4: triphenylphosphine / tetrahydrofuran; water / 50 °C
5: triethylamine / dichloromethane / 0 - 20 °C
6: iodine; silver trifluoroacetate / chloroform; acetonitrile
View Scheme
参考文献
Khera, Manoj Kumar; Cliffe, Ian A.; Prakash, Om
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5266 - 5269
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: iodine; silver trifluoroacetate / acetonitrile / 24 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039
