potassium hydroxide T=20°C; Knoevenagel condensation; 0.5 h; neat (no solvent);

1: 2-cyano-3-(4-trifluoromethyl-phenyl)-propionic acid ethyl ester With potassium hydride in acetonitrile T=20°C; 0.333333 h; Inert atmosphereGlovebox; 2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium in acetonitrile T=24.84°C; Inert atmosphereGlovebox; Thermodynamic data;

in acetonitrile T=20°C; Reduction; oxidation; 22 h; Kinetics; Further Variations:Temperatures;