L-3,3-二苯基丙氨酸合成路线 （共 11 条）
反应条件
1: With hydrogenchloride; hydrogen; palladium(II) hydroxide/carbon in tetrahydrofuran; water T=50°C; P=16501.7 Torr; 100 h; 2: With hydrogenchloride; water T=120 - 130°C; 2.5 h; Heating / reflux; 3: With sodium hydroxide; water T=0°C; pH=6 - 7; Product distribution / selectivity;
参考文献
Kaneka Corporation
Patent: EP2050738 A1, 2009 ;
Location in patent: Page/Page column 39-40 ;
反应条件
1: With hydrogenchloride; water 5 h; Heating / reflux; 2: With sodium hydroxide; water
参考文献
EP2050738 A1, ;
Page/Page column 40 ;
反应条件
lithium hydroxide; tetrabutylammomium bromide; lithium bromide in acetonitrile 8 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 11 p. 1586 - 1601
反应条件
1: 89 percent / 0.5 N aq. HCl, silica gel / CHCl3 / 2 h / 40 °C 2: LiBr, tetrabutylammonium bromide, LiOH*H2O / acetonitrile / 8 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 11 p. 1586 - 1601
反应条件
1: 1.) n-BuLi, HMPA / 1.) hexane, THF, from -78 deg C to RT, 2.) hexane, THF, RT, 5 d 2: 89 percent / 0.5 N aq. HCl, silica gel / CHCl3 / 2 h / 40 °C 3: LiBr, tetrabutylammonium bromide, LiOH*H2O / acetonitrile / 8 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 11 p. 1586 - 1601
反应条件
sulfuric acid in methanol; water T=25°C; Resolution of racemate;
参考文献
Bulletin of the Korean Chemical Society, , vol. 33, # 10 p. 3481 - 3484
反应条件
hydrogenchloride; sodium hydride 1.) CH3CN, RT, 2 h, 2.) MeOH, reflux, 20 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 1 p. 79 - 83
反应条件
1: With sodium hydroxide; sodium carbonate in water T=20°C; 2 h; 2: With hydrogenchloride in water
参考文献
AMBRILIA BIOPHARMA INC.
Patent: WO2006/114001 A1, 2006 ;
Location in patent: Page/Page column 74 ;
WO 2006/114001 A1
反应条件
sodium hydroxide; sodium carbonate in water T=20°C; 2 h;
参考文献
Stranix, Brent Richard; Perron, Valerie
Patent: US2006/25592 A1, 2006 ;
Location in patent: Page/Page column 20 ;
参考文献
Jones, Kristen L.G.; Holloway, M. Katharine; Su, Hua-Poo; Carroll, Steven S.; Burlein, Christine; Touch, Sinoeun; DiStefano, Daniel J.; Sanchez, Rosa I.; Williams, Theresa M.; Vacca, Joseph P.; Coburn, Craig A.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 14 p. 4065 - 4068
