1,4-二苄基-3-氧代哌嗪-2-羧酸乙酯合成路线 （共 3 条）
反应条件
in acetonitrile 18 h; Reflux;
参考文献
Hilfiker, Mark A.; Zhang, Daohua; Dowdell, Sarah E.; Goodman, Krista B.; McAtee, John J.; Dodson, Jason W.; Viet, Andrew Q.; Wang, Gren Z.; Sehon, Clark A.; Behm, David J.; Wu, Zining; Carballo, Luz H.; Douglas, Stephen A.; Neeb, Michael J.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4470 - 4473
反应条件
hydrogen; palladium on activated charcoal in ethanol 24 h; Ambient temperature;
参考文献
Hilfiker, Mark A.; Zhang, Daohua; Dowdell, Sarah E.; Goodman, Krista B.; McAtee, John J.; Dodson, Jason W.; Viet, Andrew Q.; Wang, Gren Z.; Sehon, Clark A.; Behm, David J.; Wu, Zining; Carballo, Luz H.; Douglas, Stephen A.; Neeb, Michael J.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4470 - 4473
反应条件
1: 88 percent / H2 / 5percent Pd/C / ethanol / 24 h / Ambient temperature 2: 67 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Ambient temperature View Scheme
参考文献
Naylor; Judd; Lloyd; Scopes; Hayes; Birch
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2075 - 2083
