2-氨基-4-三氟甲基嘧啶-5-羧酸乙酯合成路线 （共 8 条）
反应条件
1: 1-methylguanidine hydrochloride With sodium ethanolate in ethanol T=20°C; 1 h; 2: 3-methoxy-2-(2,2,2-trifluoro-acetyl)-acrylic acid ethyl ester in ethanol; dichloromethane T=20°C; 20 h;
参考文献
Forest Laboratories Holdings Limited
Patent: US2008/58350 A1, 2008 ;
Location in patent: Page/Page column 12 ;
US 20080058350 A1
反应条件
TG thiol resin; TEA; ammonia; 3-chloro-benzenecarboperoxoic acid 1.) DMF, 1 h, 2.) CH2Cl2, 3.) CH2Cl2, 24 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 38, # 2 p. 211 - 214
反应条件
sodium ethanolate in ethanol 1 h; Heating;
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
反应条件
1: Heating 2: NaOEt / ethanol / 20 °C 3: POCl3 / 3 h / Heating 4: NH3 / tetrahydrofuran / 6 h / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2573 - 2577
反应条件
1: POCl3 / 3 h / Heating 2: NH3 / tetrahydrofuran / 6 h / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2573 - 2577
反应条件
1: NaOEt / ethanol / 20 °C 2: POCl3 / 3 h / Heating 3: NH3 / tetrahydrofuran / 6 h / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2573 - 2577
反应条件
potassium hydroxide in ethanol 5 h; Heating;
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
反应条件
1: 82 percent / KOH / aq. ethanol / 5 h / Heating 2: 74 percent / 6 h / Heating View Scheme
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
