8-Boc-3,8-二氮杂双环[3.2.1]辛烷合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Barlocco, Daniela; Cignarella, Giorgio; Tondi, Donatella; Vianello, Paola; Villa, Stefania; Bartolini, Alessandro; Ghelardini, Carla; Galeotti, Nicoletta; Anderson, David J.; Kuntzweiler, Theresa A.; Colombo, Diego; Toma, Lucio
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 674 - 681
反应条件
potassium carbonate in methanol; water T=20°C; 16 h;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.
Patent: US2005/101602 A1, 2005 ;
Location in patent: Page/Page column 26 ;
反应条件
1: CH2Cl2 / 20 °C 2: 72 percent / H2 / Pd/C / methanol / 760 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 5 p. 899 - 902
反应条件
1: 92 percent / CH2Cl2 / Ambient temperature 2: 95 percent / H2 / 10percent Pd/C / ethanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 5 p. 674 - 681
反应条件
1: toluene / 85 °C 2: xylene / Heating 3: 230 °C 4: H2; HCl / Pd/C / H2O / 85 h / 760 Torr 5: LiAlH4 / diethyl ether / Heating 6: CH2Cl2 / 20 °C 7: 72 percent / H2 / Pd/C / methanol / 760 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 5 p. 899 - 902
反应条件
1: xylene / Heating 2: 230 °C 3: H2; HCl / Pd/C / H2O / 85 h / 760 Torr 4: LiAlH4 / diethyl ether / Heating 5: CH2Cl2 / 20 °C 6: 72 percent / H2 / Pd/C / methanol / 760 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 5 p. 899 - 902
反应条件
1: LiAlH4 / diethyl ether / Heating 2: CH2Cl2 / 20 °C 3: 72 percent / H2 / Pd/C / methanol / 760 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 5 p. 899 - 902
反应条件
1: H2; HCl / Pd/C / H2O / 85 h / 760 Torr 2: LiAlH4 / diethyl ether / Heating 3: CH2Cl2 / 20 °C 4: 72 percent / H2 / Pd/C / methanol / 760 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 5 p. 899 - 902
反应条件
1: TEA / toluene / Heating 2: HCl / diethyl ether View Scheme
参考文献
Toma, Lucio; Quadrelli, Paolo; Bunnelle, William H.; Anderson, David J.; Meyer, Michael D.; Cignarella, Giorgio; Gelain, Arianna; Barlocco, Daniela
Journal of Medicinal Chemistry, 2002 , vol. 45, # 18 p. 4011 - 4017
反应条件
1: With triethylamine in dichloromethane T=0 - 20°C; 72 h; 2: With trifluoroacetic acid in 1,2-dichloro-ethane T=20°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/67108 A1, 2009 ;
Location in patent: Page/Page column 68-69 ;
WO 2009/067108 A1
