6-(二甲基氨基)-3-吡啶羧醛合成路线 （共 4 条）
反应条件
in diethyl ether; N,N-dimethyl-formamide
参考文献
Eisai Co., Ltd.
Patent: US2002/19531 A1, 2002 ;
US 20020019531 A1
反应条件
1: (5-bromo-pyridin-2-yl)-dimethylamine With magnesium; ethylene dibromide in tetrahydrofuran 2: N,N-dimethyl-formamide in tetrahydrofuran T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
反应条件
1.1: Br2; aq. Na2CO3 / CH2Cl2 / 0 °C 2.1: Mg; 1,2-dibromoethane / tetrahydrofuran 2.2: tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4787 - 4798
反应条件
1: 4-toluene-sulfonylmethyl isocyanide With potassium tert-butylate in ethylene glycol dimethyl ether T=-50°C; 2: 2-dimethylaminopyridine-5-carboxaldehyde in ethylene glycol dimethyl ether T=-50°C;
参考文献
Chen, Chen; Wilcoxen, Keith M.; Huang, Charles Q.; Xie, Yun-Feng; McCarthy, James R.; Webb, Thomas R.; Zhu, Yun-Fei; Saunders, John; Liu, Xin-Jun; Chen, Ta-Kung; Bozigian, Haig; Grigoriadis, Dimitri E.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4787 - 4798
