1: 93 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate / dimethylformamide / 1 h / 20 °C 2: Dess-Martin periodinane / CH2Cl2 / 4 h / 20 °C 3: 13 mg / NH3 / methanol / 24 h / 20 °C 4: 80 percent / trifluoroacetic acid / H2O View Scheme

1: 93 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate / dimethylformamide / 1 h / 20 °C 2: Dess-Martin periodinane / CH2Cl2 / 4 h / 20 °C 3: 13 mg / NH3 / methanol / 24 h / 20 °C View Scheme

1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 1 h;

ammonia 1.) MeOH, reflux, 4 d, 2.) MeOH, 15 min; Yield given. Multistep reaction;

1: methanol / Heating 2: NH3 / methanol / 0.17 h View Scheme