1-(乙氧基甲基)-6-(苯基甲基)-5-丙-2-基嘧啶-2,4-二酮合成路线 （共 20 条）
反应条件
hydrogen; acetic acid; palladium on activated charcoal in 1,4-dioxane T=60°C; P=760 Torr; 15 h;
参考文献
Tanaka; Takashima; Ubasawa; Sekiya; Inouye; Baba; Shigeta; Walker; De Clercq; Miyasaka
Journal of Medicinal Chemistry, 1995 , vol. 38, # 15 p. 2860 - 2865
反应条件
1: 6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione With N,O-bis-(trimethylsilyl)-acetamide in dichloromethane 2: chloromethyl-ethyl-ether With lithium iodide in dichloromethane T=20°C; 3 h;
参考文献
Li, Li; Ma, Liying; Wang, Xiaowei; Liu, Junyi
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 164 - 168
反应条件
benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate in acetonitrile T=-45 - 20°C; 3.5 h;
参考文献
Boudet, Nadege; Knochel, Paul
Organic Letters, 2006 , vol. 8, # 17 p. 3737 - 3740
反应条件
hydrogen; acetic anhydride; palladium on activated charcoal Multistep reaction;
参考文献
Nucleosides and Nucleotides, , vol. 14, # 3-5 p. 575 - 583
反应条件
1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h 2: 35percent H2O2, 1N aq. NaOH / 1 h / Ambient temperature 3: pyridine / 12 h / Ambient temperature 4: 85 percent / H2, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 15 p. 2860 - 2865
反应条件
1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h 2: 35percent H2O2, 1N aq. NaOH / 1 h / Ambient temperature 3: pyridine / 12 h / Ambient temperature 4: 85 percent / H2, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 15 p. 2860 - 2865
反应条件
1: 35percent H2O2, 1N aq. NaOH / 1 h / Ambient temperature 2: pyridine / 12 h / Ambient temperature 3: 85 percent / H2, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 15 p. 2860 - 2865
反应条件
tetra-(n-butyl)ammonium iodide T=20°C; Inert atmosphere;
参考文献
Wang, Zhengqiang; Tang, Jing; Salomon, Christine E.; Dreis, Christine D.; Vince, Robert
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4202 - 4211
反应条件
1: 72 percent / EtONa / ethanol / 6 h / Heating 2: 1.) bis(trimethylsilyl)acetamide / 1.) CHCl3, RT, 10 min, 2.) CHCl3, RT View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 12 p. 2427 - 2431
反应条件
1: 92 percent / aq. HCl / 4 h / Heating 2: 90 percent / BSA; TMS triflate / acetonitrile / 3.5 h / -45 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 17 p. 3737 - 3740
