1-(乙氧基甲基)-6-(苯基甲基)-5-丙-2-基嘧啶-2,4-二酮合成路线 （共 20 条）
反应条件
1.1: Et3SiH; TFA / CH2Cl2 / 12 h / 20 °C 1.2: 91 percent / H2 / PtO2 / ethanol / 0.5 h / 750.06 Torr 2.1: i-PrMgCl*LiCl / tetrahydrofuran / 5 h / 20 °C 2.2: 87 percent / tetrahydrofuran / 20 h / 20 °C 3.1: 92 percent / aq. HCl / 4 h / Heating 4.1: 90 percent / BSA; TMS triflate / acetonitrile / 3.5 h / -45 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 17 p. 3737 - 3740
反应条件
1.1: i-PrMgCl*LiCl / tetrahydrofuran / 5 h / 20 °C 1.2: 87 percent / tetrahydrofuran / 20 h / 20 °C 2.1: 92 percent / aq. HCl / 4 h / Heating 3.1: 90 percent / BSA; TMS triflate / acetonitrile / 3.5 h / -45 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 8, # 17 p. 3737 - 3740
反应条件
1: 92 percent / Zn / tetrahydrofuran / 0.17 h / Heating 2: 72 percent / EtONa / ethanol / 6 h / Heating 3: 1.) bis(trimethylsilyl)acetamide / 1.) CHCl3, RT, 10 min, 2.) CHCl3, RT View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 12 p. 2427 - 2431
反应条件
1: 92 percent / Zn / tetrahydrofuran / 0.17 h / Heating 2: 72 percent / EtONa / ethanol / 6 h / Heating 3: 1.) bis(trimethylsilyl)acetamide / 1.) CHCl3, RT, 10 min, 2.) CHCl3, RT View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 12 p. 2427 - 2431
反应条件
1: 93 percent / tetrahydrofuran / -78 °C 2: 95 percent / NaOMe / 4 h / Heating 3: 85 percent / HCl / H2O / 3 h / Heating 4: 1) HMDS, Me3SiCl, 2) stannic chloride / 1) reflux, 2) CH3CN, room temperature, 10 h View Scheme
参考文献
Synthetic Communications, , vol. 29, # 9 p. 1503 - 1517
反应条件
1: 95 percent / NaOMe / 4 h / Heating 2: 85 percent / HCl / H2O / 3 h / Heating 3: 1) HMDS, Me3SiCl, 2) stannic chloride / 1) reflux, 2) CH3CN, room temperature, 10 h View Scheme
参考文献
Synthetic Communications, , vol. 29, # 9 p. 1503 - 1517
反应条件
1: 93 percent / tetrahydrofuran / -78 °C 2: 95 percent / NaOMe / 4 h / Heating 3: 85 percent / HCl / H2O / 3 h / Heating 4: 1) HMDS, Me3SiCl, 2) stannic chloride / 1) reflux, 2) CH3CN, room temperature, 10 h View Scheme
参考文献
Synthetic Communications, , vol. 29, # 9 p. 1503 - 1517
反应条件
1.1: chloroacetic acid / water / 24 h / |Reflux 2.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane 2.2: 3 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 50, # 1 p. 164 - 168
反应条件
1.1: pyridine / dichloromethane / 2 h / 0 - 20 °C 1.2: 2.5 h / |Reflux 2.1: potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: sodium ethanolate / ethanol / 6 h / |Reflux 4.1: chloroacetic acid / water / 24 h / |Reflux 5.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane 5.2: 3 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 50, # 1 p. 164 - 168
反应条件
1.1: potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 12 h / 20 °C 2.1: sodium ethanolate / ethanol / 6 h / |Reflux 3.1: chloroacetic acid / water / 24 h / |Reflux 4.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane 4.2: 3 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 50, # 1 p. 164 - 168
