(E)-2-[3-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-氧代丙基]苯甲酸甲酯合成路线 （共 30 条）
反应条件
tetrabutylammomium bromide; triethylamine; palladium diacetate in toluene T=80°C; 6 h; Product distribution / selectivity;
参考文献
GLADE ORGANICS PRIVATE LIMITED
Patent: WO2006/131782 A1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
lithium chloride; palladium diacetate in hexane; ethyl acetate; N,N-dimethyl-formamide; toluene
参考文献
US5212180 A1, ;
US 5212180 A
反应条件
hydrogenchloride; water in acetic acid T=25 - 65°C; 10 - 12 h;
参考文献
WO2006/21974 A1, ;
Page/Page column 23-24 ;
反应条件
palladium diacetate; triethylamine; tris-(o-tolyl)phosphine in toluene T=100°C; 1 h; other reagent: triphenylphosphine;
参考文献
Larsen, Robert D.; Corley, Edward G.; King, Anthony O.; Carroll, James D.; Davis, Paul; Verhoeven, Thomas R.; Reider, Paul J.; Labelle, Marc; Gauthier, Jacques Y.; Xiang, Yi Bin; Zamboni, Robert J.
Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3398 - 3405
反应条件
palladium diacetate; triethylamine; triphenylphosphine; lithium bromide in toluene T=100°C; 6 h; other reagent: tri-o-tolylphosphine;
参考文献
Larsen, Robert D.; Corley, Edward G.; King, Anthony O.; Carroll, James D.; Davis, Paul; Verhoeven, Thomas R.; Reider, Paul J.; Labelle, Marc; Gauthier, Jacques Y.; Xiang, Yi Bin; Zamboni, Robert J.
Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3398 - 3405
反应条件
1: (E)-2-(3-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-oxo-propyl)-benzoic acid With potassium carbonate in acetone T=30°C; 0.5 h; 2: methyl iodide in acetone T=55°C; 12 h; Product distribution / selectivity;
参考文献
WO2008/58118 A2, ;
Page/Page column 30-31 ;
反应条件
1: 1.) NaOH, 2.) HCl / 1.) aq. ethanol, room temperature, 20 h, 2.) water, ethanol, 5 deg C, 5 h 2: NaOH / ethanol 3: 88 percent / NaOH, hydrogen / tris(triphenylphosphine)rhodium(I) chloride / ethanol / 2068.6 Torr / Ambient temperature 4: 88 percent / sulfuric acid / 17 h / Heating 5: 92 percent / triethylamine / CH2Cl2 / 0 °C 6: 66 percent / palladium(II) acetate, triphenylphosphine, lithium bromide, triethylamine / toluene / 6 h / 100 °C / other reagent: tri-o-tolylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
反应条件
1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 14 p. 3731 - 3735
反应条件
acetic anhydride T=140°C; 8 h;
参考文献
He, Liang; Guo, Yang Hui; Wang, Ya Ping; Wang, Xiang Jing; Zhang, Ji; Xiang, Wen Sheng
Chinese Chemical Letters, 2012 , vol. 23, # 5 p. 518 - 520
反应条件
1: 1.) NaOH, 2.) HCl / 1.) aq. ethanol, room temperature, 20 h, 2.) water, ethanol, 5 deg C, 5 h 2: NaOH / ethanol 3: 88 percent / NaOH, hydrogen / tris(triphenylphosphine)rhodium(I) chloride / ethanol / 2068.6 Torr / Ambient temperature 4: 88 percent / sulfuric acid / 17 h / Heating 5: 92 percent / triethylamine / CH2Cl2 / 0 °C 6: 66 percent / palladium(II) acetate, triphenylphosphine, lithium bromide, triethylamine / toluene / 6 h / 100 °C / other reagent: tri-o-tolylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
