(E)-2-[3-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-氧代丙基]苯甲酸甲酯合成路线 （共 30 条）
反应条件
1: 1.) NaOH, 2.) H2SO4 / 1.) aq. ethanol, 0 -> 20 deg C, 2.) aq. ethanol, 60 deg C -> room temperature 2: 96 percent / NaOH, hydrogen / tris(triphenylphosphine)rhodium(I) chloride / ethanol / 16 h / 2068.6 Torr / Ambient temperature 3: 92 percent / sulfuric acid / 24 h / Heating 4: 91 percent / palladium(II) acetate, tri-o-tolylphosphine, triethylamine / toluene / 1 h / 100 °C / other reagent: triphenylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
反应条件
1: 96 percent / NaOH, hydrogen / tris(triphenylphosphine)rhodium(I) chloride / ethanol / 16 h / 2068.6 Torr / Ambient temperature 2: 92 percent / sulfuric acid / 24 h / Heating 3: 91 percent / palladium(II) acetate, tri-o-tolylphosphine, triethylamine / toluene / 1 h / 100 °C / other reagent: triphenylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
反应条件
1: NaOH / ethanol 2: 88 percent / NaOH, hydrogen / tris(triphenylphosphine)rhodium(I) chloride / ethanol / 2068.6 Torr / Ambient temperature 3: 88 percent / sulfuric acid / 17 h / Heating 4: 92 percent / triethylamine / CH2Cl2 / 0 °C 5: 66 percent / palladium(II) acetate, triphenylphosphine, lithium bromide, triethylamine / toluene / 6 h / 100 °C / other reagent: tri-o-tolylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
反应条件
1: triethylamine / H2O; ethanol / 3 h 2: ethanol / 2 h 3: triethylamine / H2O; ethanol / 16 h / Heating 4: 91 percent / palladium(II) acetate, tri-o-tolylphosphine, triethylamine / toluene / 1 h / 100 °C / other reagent: triphenylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
反应条件
1: 88 percent / sulfuric acid / 17 h / Heating 2: 92 percent / triethylamine / CH2Cl2 / 0 °C 3: 66 percent / palladium(II) acetate, triphenylphosphine, lithium bromide, triethylamine / toluene / 6 h / 100 °C / other reagent: tri-o-tolylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
反应条件
1: 92 percent / sulfuric acid / 24 h / Heating 2: 91 percent / palladium(II) acetate, tri-o-tolylphosphine, triethylamine / toluene / 1 h / 100 °C / other reagent: triphenylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
反应条件
1: 92 percent / triethylamine / CH2Cl2 / 0 °C 2: 66 percent / palladium(II) acetate, triphenylphosphine, lithium bromide, triethylamine / toluene / 6 h / 100 °C / other reagent: tri-o-tolylphosphine View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 10 p. 3398 - 3405
反应条件
1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 °C 2: n-butyllithium / tetrahydrofuran / -20 °C 3: N-bromosuccinmide; water / acetonitrile / 0.5 h / -20 - -10 °C 4: acetic anhydride / 8 h / 140 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 23, # 5 p. 518 - 520
反应条件
1: n-butyllithium / tetrahydrofuran / -20 °C 2: N-bromosuccinmide; water / acetonitrile / 0.5 h / -20 - -10 °C 3: acetic anhydride / 8 h / 140 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 23, # 5 p. 518 - 520
反应条件
1: With N-ethyl-N,N-diisopropylamine; bis[(1S,2R,3S,5S)-pinan-3-yl]chloroborane in dichloromethane T=-5 - 0°C; 3.75 - 4.75 h; 2: With triethanolamine in dichloromethane T=20 - 30°C; 2 h;
参考文献
CIPLA LIMITED; CURTIS, Philip, Anthony
Patent: WO2008/32099 A2, 2008 ;
Location in patent: Page/Page column 21-22 ;
