hydrogenchloride; N-lt;lt;lt;(benzyloxycarbonyl)aminogt;methylgt;hydroxyphosphinylgt;-L-phenylalanine; tri-(hydroxymethyl)-methylamine; sodium chloride; carboxypeptidase A in water T=25°C; competitive inhibition (rapid and reversible) of CPA-catalyzed peptide hydrolysis, Ki at this pH and pH = 6.0; effect of added ZnCl2 on inhibition; Mechanism;
参考文献
Journal of the American Chemical Society, , vol. 103, p. 654
hydrogenchloride; N-lt;lt;lt;(benzyloxycarbonyl)aminogt;methylgt;hydroxyphosphinylgt;-L-phenylalanine; tri-(hydroxymethyl)-methylamine; sodium chloride; carboxypeptidase A in water T=25°C; competitive inhibition of CPA-catalyzed peptide hydrolysis, Ki; Michaelis-Menton kinetics; Mechanism;
参考文献
Journal of the American Chemical Society, , vol. 103, p. 654
hydrogenchloride in water T=21°C; 0.166667 h; hydrolytic stability (half-life) at various pH; the presence of carboxypeptidase A does not effect the rate of hydrolysis; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 103, p. 654
1: 1 M ethylchloroformate, 0.04 M N-methylmorpholine, 0.01 M HCl / tetrahydrofuran / 0.05 h / Ambient temperature 2: 0.02 M HCl / 0.17 h 3: 1 N aq. HCl / diethyl ether View Scheme
