反应条件
1: 1.) n-butyllithium / 1.) THF, 0 deg C, reflux 4 h, 2.) ether, 0 deg C, reflux 5 h
2: 1.) sodium hydride / 1.) THF, reflux, 16 h, 2.) THF, 0 deg C, 15 min, 20 deg C, 10 h
3: 24 percent / POCl3 / 0.17 h / 100 °C
4: 70 percent / NH4OAc / 2 h / 100 °C
5: 95 percent / aluminium hydride, 100percent H2SO4 / tetrahydrofuran / 0 deg C, 20 deg C 1 h followed 30 min reflux
6: 57 percent / TMSCl, Et3N, TMSI / CH2Cl2; CHCl3
7: 89 percent / Et3N / diethyl ether / 1 h / 0 - 35 °C
8: 96 percent / pyridine / 12 h / 0 °C
9: 55 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Heating
10: 86 percent / KOH / H2O; propan-2-ol / 0.5 h / 45 °C
View Scheme
参考文献
Gerdes, John M.; Mathis, Chester A.; Shulgin, Alexander T.
Tetrahedron Letters, 1988 , vol. 29, # 50 p. 6537 - 6540
