4-氨基-7h-吡咯并[2,3-d]嘧啶-5-甲腈合成路线 （共 5 条）
反应条件
boron trichloride in dichloromethane a) - 78 deg C, 2 h, b) -60 deg C, 4 h;
参考文献
Gupta, Pranab K.; Daunert, Sylvia; Nassiri, M. Reza; Wotring, Linda L.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 402 - 408
反应条件
ammonium hydroxide; 10 Pd/C; hydrogen in ethanol; water 12 h;
参考文献
Wilding, Birgit; Winkler, Margit; Petschacher, Barbara; Kratzer, Regina; Glieder, Anton; Klempier, Norbert
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2191 - 2198
反应条件
1: 48 percent / hydrogen / 5percent Pd/C, MgO / ethyl acetate / 6 h / 2482.3 Torr 2: 10 percent / boron trichloride / CH2Cl2 / a) - 78 deg C, 2 h, b) -60 deg C, 4 h View Scheme
参考文献
Gupta, Pranab K.; Daunert, Sylvia; Nassiri, M. Reza; Wotring, Linda L.; Drach, John C.; Townsend, Leroy B.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 402 - 408
反应条件
1: 2-ethoxy-ethanol / 41 h / |Reflux 2: ammonium hydroxide; 10 Pd/C; hydrogen / water; ethanol / 12 h View Scheme
参考文献
Wilding, Birgit; Winkler, Margit; Petschacher, Barbara; Kratzer, Regina; Glieder, Anton; Klempier, Norbert
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2191 - 2198
反应条件
1: hydrogen bromide; acetic acid / acetone; ethyl acetate / 3 h / -5 °C 2: 2-ethoxy-ethanol / 41 h / |Reflux 3: ammonium hydroxide; 10 Pd/C; hydrogen / water; ethanol / 12 h View Scheme
参考文献
Wilding, Birgit; Winkler, Margit; Petschacher, Barbara; Kratzer, Regina; Glieder, Anton; Klempier, Norbert
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 11-12 p. 2191 - 2198
