8-(1,3-苯并-5-二氧基)-1,4-二噁螺[4.5]癸烷-8-醇合成路线 （共 6 条）
参考文献
Bristol-Myers Squibb
Patent: US5391570 A1, 1995 ;
US 5391570 A
反应条件
1.1: 90 percent / N-bromosuccinimide / CHCl3 / 3.5 h / Heating 2.1: n-BuLi / diethyl ether; hexane / 0.17 h / -30 °C 2.2: 80 percent / tetrahydrofuran; diethyl ether; hexane / 2 h / 20 °C View Scheme
参考文献
Magnus; Bailey; Porter
Tetrahedron, 1999 , vol. 55, # 49 p. 13927 - 13936
参考文献
Mattson, Ronald J; Catt, John D; Sloan, Charles P; Gao; Carter, Richard B; Gentile, Anthony; Mahle, Cathy D; Matos, F Fatima; McGovern, Rachel; VanderMaelen, Cam P; Yocca, Frank D
Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 285 - 288
反应条件
hydrogenchloride in water; acetone
参考文献
Bristol-Myers Squibb
Patent: US5391570 A1, 1995 ;
US 5391570 A
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate in pyridine T=20 - 80°C; Dehydration;
参考文献
Magnus; Bailey; Porter
Tetrahedron, 1999 , vol. 55, # 49 p. 13927 - 13936
反应条件
1: 97 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene; POCl3 / pyridine / 20 - 80 °C
2: H2 / Pd/C / methanol; tetrahydrofuran / 20 h
3: conc. sulfuric acid / tetrahydrofuran; H2O / 1.5 h
View Scheme
参考文献
Magnus; Bailey; Porter
Tetrahedron, 1999 , vol. 55, # 49 p. 13927 - 13936
