2-溴-6-[(叔丁基二甲基甲硅烷基氧基)甲基]吡啶合成路线 （共 5 条）
反应条件
1H-imidazole; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C;
参考文献
ASTRAZENECA AB
Patent: US2008/51405 A1, 2008 ;
Location in patent: Page/Page column 19 ;
US 20080051405 A1
参考文献
Schering Corporation
Patent: US2003/119847 A1, 2003 ;
反应条件
2: 89 percent / imidazole / dimethylformamide / 0.25 h / Ambient temperature View Scheme
参考文献
Maindron, Nicolas; Poupart, Severine; Hamon, Maxime; Langlois, Jean-Baptiste; Ple, Nelly; Jean, Ludovic; Romieu, Anthony; Renard, Pierre-Yves
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2357 - 2370
反应条件
1: 1) BuLi / 1) THF-Et2O-hexane, -78 deg C, 2) -78 deg C -> -50 deg C 2: NaBH4 / methanol / Ambient temperature View Scheme
参考文献
Tsukube, Hiroshi; Uenishi, Jun'ichi; Higaki, Hiromi; Kikkawa, Ken'ichi; Tanaka, Takakazu; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4389 - 4397
反应条件
1: 2-bromo-6-(((tert-butyldimethylsilyl)oxy)methyl)pyridine With n-butyllithium in tetrahydrofuran; diethyl ether; hexane T=-78°C; 0.0833333 - 0.166667 h; 2: N,N-dimethyl acetamide in tetrahydrofuran; diethyl ether; hexane T=-78°C; 0.5 h;
参考文献
TRIGEN LIMITED
Patent: WO2005/12323 A2, 2005 ;
Location in patent: Page/Page column 49 ;
WO 2005/012323 A2
