反应条件
1: 1) n-BuLi, 2) CuCl / 1) THF, hexane, -78 deg C, 20 min, 2) THF, a) -78 deg C, 45 min, b) to 5 deg C 2: S-Alpine-borane / tetrahydrofuran / 15 h / 23 °C 3: 99 percent / imidazole / dimethylformamide / 2.5 h / 23 °C 4: 82 percent / Br2, 1,2-bis(diphenylphosphino)ethane / CH2Cl2 / 0.08 h / 0 °C 5: 1) NaN(SiMe3)2 / 1) THF, -10 deg C, 15 min, 2) THF, -10 deg C, 1 h 6: 1) LiN(SiMe3)2 / 1) THF, -78 deg C, 1 h, 2) THF, a) -78 deg C, 1 h, b) -20 deg C, 1 h, c) 0 deg C, 1 h 7: 88 percent / H2, quinoline / BaSO4/Pd / ethyl acetate / 4 h / 23 °C 8: 82 percent / n-Bu4NF / tetrahydrofuran / 14 h / 23 °C View Scheme
参考文献
Nicolaou, K. C.; Zipkin, R. E.; Dolle, R. E.; Harris, B. D.
Journal of the American Chemical Society, 1984 , vol. 106, # 12 p. 3548 - 3551
