反应条件
1: 1.) O3, NaHCO3, 2.) triethylamine, Ac2O / 1.) CH2Cl2, -78 deg C, 3 h, 2.) CH2Cl2, 23 deg C, 5 h
2: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, from -78 deg C to 0 deg C, 35 min, 2.) THF, 23 deg C, 1 h
3: 96 percent / H2 / 10percent Pd/C / toluene / 12 h / 60 °C
View Scheme
参考文献
Myers, Andrew G.; Gin, David Y.; Rogers, Daniel H.
Journal of the American Chemical Society, 1994 , vol. 116, # 11 p. 4697 - 4718
