四乙基(4-羟基-1,1-丁烷二基)二(膦酸酯)合成路线 （共 5 条）
反应条件
Amberlyst H15 in methanol T=45°C; 1 h;
参考文献
Gourves, Jean-Philippe; Couthon, Helene; Sturtz, Georges
Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 132, p. 219 - 229
反应条件
1.1: toluene 2.1: BH3*THF / tetrahydrofuran / 1.5 h / 0 °C 2.2: 68 percent / 30percent H2O2; 3 M aq. NaOH / methanol; tetrahydrofuran / 1 h / 50 °C View Scheme
参考文献
Kultyshev, Roman G.; Liu, Jianping; Liu, Shengming; Tjarks, Werner; Soloway, Albert H.; Shore, Sheldon G.
Journal of the American Chemical Society, 2002 , vol. 124, # 11 p. 2614 - 2624
反应条件
in methanol; ethyl acetate
参考文献
TARGANTA THERAPEUTICS, INC.
Patent: US2010/113333 A1, 2010 ;
反应条件
1: With sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical in water; acetonitrile T=20 - 35°C; 22 h; Aqueous phosphate buffer; 2: With sodium hydroxide in water; acetonitrile pH=8.0; 3: With hydrogenchloride in water pH=3.4; Product distribution / selectivity;
参考文献
TARGANTA THERAPEUTICS, INC.
Patent: US2010/113333 A1, 2010 ;
反应条件
1: 84 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature
2: 80 percent / NaN3 / dimethylformamide / 12 h / Ambient temperature
3: Ph3P, H2O / tetrahydrofuran / 12 h
View Scheme
参考文献
Gourves, Jean-Philippe; Couthon, Helene; Sturtz, Georges
Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 132, p. 219 - 229
