N-戊酰基氨基环戊烷-1-羧酸合成路线 （共 10 条）
反应条件
1: With sodium hydroxide; tetrabutylammomium bromide in water; toluene T=0 - 5°C; 2 h; 2: in water Acidic aqueous solution; Product distribution / selectivity;
参考文献
ALEMBIC LIMITED
Patent: WO2007/49293 A1, 2007 ;
Location in patent: Page/Page column 20; 24-25 ;
反应条件
hydrogenchloride T=55 - 60°C; 2 h;
参考文献
Rao, Korrapati V. V. Prasada; Dandala, Ramesh; Handa, Vijay K.; Rao, Inti V. Subramanyeswara; Rani, Ananta; Naidu, Andra
Synthetic Communications, 2007 , vol. 37, # 17 p. 2897 - 2905
反应条件
sodium hydroxide in water; toluene T=0 - 10°C; 2 h;
参考文献
Satyanarayana, Bollikonda; Sumalatha, Yasareni; Sridhar, Chaganti; Venkatraman, Sundaram; Reddy, Padi Pratap
Heterocyclic Communications, 2006 , vol. 12, # 5 p. 323 - 328
反应条件
1: triethylamine / CH2Cl2 / 2.67 h / 0 - 5 °C 2: 654 g / aq. hydrochloric acid / 2 h / 55 - 60 °C View Scheme
参考文献
Rao, Korrapati V. V. Prasada; Dandala, Ramesh; Handa, Vijay K.; Rao, Inti V. Subramanyeswara; Rani, Ananta; Naidu, Andra
Synthetic Communications, 2007 , vol. 37, # 17 p. 2897 - 2905
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane T=25 - 35°C;
参考文献
Satyanarayana, Bollikonda; Sumalatha, Yasareni; Sridhar, Chaganti; Venkatraman, Sundaram; Reddy, Padi Pratap
Heterocyclic Communications, 2006 , vol. 12, # 5 p. 323 - 328
反应条件
benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide in dichloromethane T=38 - 41°C; 7 h;
参考文献
Rao, Korrapati V. V. Prasada; Dandala, Ramesh; Handa, Vijay K.; Rao, Inti V. Subramanyeswara; Rani, Ananta; Naidu, Andra
Synthetic Communications, 2007 , vol. 37, # 17 p. 2897 - 2905
反应条件
1: 93 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; diisopropylethylamine / CH2Cl2 / 7 h / 38 - 41 °C 2: 71 percent / sodium azide; tributyltin chloride; N,N-dimethylformamide / o-xylene / 20 h / 150 - 155 °C View Scheme
参考文献
Prasada Rao, Korrapati V. V.; Dandala, Ramesh; Handa, Vijay K.; Subramanyeswara Rao, Inti V.; Rani, Ananta; Shivashankar, Sripelly; Naidu, Andra
Synlett, 2007 , # 8 p. 1289 - 1293
反应条件
1: With methanesulfonic acid in toluene T=20°C; 48 h; Heating / reflux; 2: With sodium hydroxide in water; ethyl acetate 0.5 h;
参考文献
ALEMBIC LIMITED
Patent: WO2007/49293 A1, 2007 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: With methanesulfonic acid in toluene T=20°C; 48 h; Heating / reflux; 2: With sodium hydroxide in water; toluene 0.5 h; Product distribution / selectivity;
参考文献
ALEMBIC LIMITED
Patent: WO2007/49293 A1, 2007 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: 96 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH2Cl2 / 25 - 35 °C 2: 81 percent / trifluoro acetic acid / toluene / Heating View Scheme
参考文献
Satyanarayana, Bollikonda; Sumalatha, Yasareni; Sridhar, Chaganti; Venkatraman, Sundaram; Reddy, Padi Pratap
Heterocyclic Communications, 2006 , vol. 12, # 5 p. 323 - 328
