(S)-(+)-2-苯甘氨酸甲酯 盐酸盐合成路线 （共 38 条）
反应条件
(−)-O,O′-di-pivaloyl-L-tartaric acid; lithium (R)-N-methyl-N-α-methylbenzyl amide other lithium amides and diacyltartaric acides; Product distribution;
参考文献
Tetrahedron Letters, , vol. 21, p. 2521 - 2524
反应条件
multistep reaction; deracemisation was investigated by means of dipivaloyltartaric acids of different chirality in the presence of chiral amines of structure Ph-CHCH3-NHR; other temperature, acid, base; Product distribution;
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 1-2 p. 75 - 83
反应条件
1: potassium carbonate / dichloromethane; water / 0 °C 2: sodium tetrahydroborate / dichloromethane; methanol / 0 °C 3: potassium tert-butylate / isopropyl alcohol / 0 °C View Scheme
参考文献
Bonilla-Landa, Israel; Viveros-Ceballos, Jose Luis; Ordonez, Mario
Tetrahedron Asymmetry, 2014 , vol. 25, # 6-7 p. 485 - 487
反应条件
triethylamine in tetrahydrofuran; ethyl acetate
参考文献
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Patent: US5866685 A1, 1999 ;
反应条件
hydrogenchloride; hydrogen in methanol; water T=20°C; P=760.051 Torr; 24 h;
参考文献
Falini, Giuseppe; Gualandi, Andrea; Savoia, Diego
Synthesis, 2009 , # 14 art. no. Z02609SS, p. 2440 - 2446
反应条件
α-amino ester hydrolase from Xanthomonas campestris pv. campestris (ATCC 33913) T=25°C; pH=6.2; aq. phosphate bufferEnzymatic reaction;
参考文献
Blum, Janna K.; Bommarius, Andreas S.
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 67, # 1-2 p. 21 - 28
反应条件
sodium hydrogen telluride in N,N-dimethyl-formamide T=70°C; 4 h;
参考文献
Synthetic Communications, , vol. 25, # 4 p. 553 - 559
反应条件
α-amino ester hydrolase from Xanthomonas campestris pv. campestris (ATCC 33913) T=25°C; pH=6.2; aq. phosphate bufferEnzymatic reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 67, # 1-2 p. 21 - 28
反应条件
anhydrous trisodium citrate in acetonitrile T=37°C; Strecker degradation; pH=4; 21 h; Product distribution; Further Variations:TemperaturespH-valuesReagents;
参考文献
Zamora, Rosario; Gallardo, Emerenciana; Hidalgo, Francisco J.
Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 6 p. 2398 - 2404
反应条件
1: dioxane / 18 h / Ambient temperature 2: DIBAH / CH2Cl2; toluene / 2 h / -78 °C 3: NaBH4 / methanol / 0.5 h / 0 °C View Scheme
参考文献
Dondoni; Perrone; Semola
Synthesis, 1995 , # 2 p. 181 - 186
