(S)-(+)-2-苯甘氨酸甲酯 盐酸盐合成路线 （共 38 条）
反应条件
sodium tetrahydroborate in ethanol 1) RT, 9h, b) 5.5h, reflux, c) RT, 8h;
参考文献
Chang, Zen-Yu; Coates, Robert M.
Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3475 - 3483
反应条件
1: dioxane / 18 h / Ambient temperature 2: DIBAH / CH2Cl2; toluene / 2 h / -78 °C 3: NaBH4 / methanol / 0.5 h / 0 °C View Scheme
参考文献
Dondoni; Perrone; Semola
Synthesis, 1995 , # 2 p. 181 - 186
反应条件
1: (S)-(+)-2-phenylglycine methyl ester hydrochloride With sodium hydrogencarbonate in water Cooling; 2: acetic anhydride in water 0.25 h; Cooling with ice;
参考文献
Kudelko, Agnieszka; Zielinski, Wojciech
Tetrahedron, 2009 , vol. 65, # 6 p. 1200 - 1206
反应条件
hydrogenchloride; hydrogen in methanol; water T=20°C; P=760.051 Torr; 24 h;
参考文献
Falini, Giuseppe; Gualandi, Andrea; Savoia, Diego
Synthesis, 2009 , # 14 art. no. Z02609SS, p. 2440 - 2446
反应条件
in diethyl ether Cooling with iceReflux;
参考文献
Kristensen, Tor E.; Vestli, Kristian; Hansen, Finn K.; Hansen, Tore
European Journal of Organic Chemistry, 2009 , # 30 p. 5185 - 5191
反应条件
in diethyl ether T=0 - 20°C;
参考文献
Dragoli; Burdett; Ellman
Journal of the American Chemical Society, 2001 , vol. 123, # 41 p. 10127 - 10128
反应条件
1: dioxane / 18 h / Ambient temperature 2: DIBAH / CH2Cl2; toluene / 2 h / -78 °C 3: NaBH4 / methanol / 0.5 h / 0 °C View Scheme
参考文献
Dondoni; Perrone; Semola
Synthesis, 1995 , # 2 p. 181 - 186
反应条件
4-(N,N-dimethlyamino)pyridine; 1-[3-(dimethylamino)-propyl]-3-ethylcarbodiimide methiodide in dichloromethane
T=20°C; 8 h;
参考文献
Sivasubramanian, Karthikeyan; Kaanumalle, Lakshmi S.; Uppili, Sundararajan; Ramamurthy
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 10 p. 1569 - 1576
