甲基 3-苯基-DL-丙氨酸酯合成路线 （共 43 条）
反应条件
1: DL-phenylalanine methyl ester; 2-(dimethylamino)-4-oxo-4H-pyridolt;1,2-agt;pyrimidine-3-carbaldehyde in toluene T=85°C; 1 h; 2: propynoic acid methyl ester in toluene T=15°C; 72 h; Further stages.;
参考文献
Kawashima, Keisuke; Hiromoto, Masanori; Hayashi, Kyohei; Kakehi, Akikazu; Shiro, Motoo; Noguchi, Michihiko
Tetrahedron Letters, 2007 , vol. 48, # 6 p. 941 - 944
反应条件
1: DL-phenylalanine methyl ester; 2-(dimethylamino)-4-oxo-4H-pyridolt;1,2-agt;pyrimidine-3-carbaldehyde in toluene T=85°C; 1 h; 2: propynoic acid methyl ester in toluene T=85°C; 22 h; Further stages.;
参考文献
Kawashima, Keisuke; Hiromoto, Masanori; Hayashi, Kyohei; Kakehi, Akikazu; Shiro, Motoo; Noguchi, Michihiko
Tetrahedron Letters, 2007 , vol. 48, # 6 p. 941 - 944
反应条件
methanol; Catalyst M-Chromium oxide; copper(II) oxide T=175°C; P=128714 - 183877 Torr;
参考文献
Journal of Biological Chemistry, , vol. 125, p. 709,711
反应条件
1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C / Cooling with ice 2: piperidine / dichloromethane / 2 h View Scheme
参考文献
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH; GOVINDARAJU, Thimmaiah
Patent: WO2011/55247 A1, 2011 ;
反应条件
Aliquatreg; 336 in tetrahydrofuran T=-20°C; Title compound not separated from byproducts;
参考文献
Arseniyadis, Stellios; Subhash, Pithani V.; Valleix, Alain; Mathew, Suju P.; Blackmond, Donna G.; Wagner, Alain; Mioskowski, Charles
Journal of the American Chemical Society, 2005 , vol. 127, # 17 p. 6138 - 6139
反应条件
in benzene T=20°C; 3 h; Title compound not separated from byproducts;
参考文献
Arseniyadis, Stellios; Subhash, Pithani V.; Valleix, Alain; Wagner, Alain; Mioskowski, Charles
Chemical Communications, 2005 , # 26 p. 3310 - 3312
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Sabot, Cyrille; Subhash, Pithani V.; Valleix, Alain; Arseniyadis, Stellios; Mioskowski, Charles
Synlett, 2008 , # 2 p. 268 - 272
反应条件
Bacillus licheniformis; sodium hydrogencarbonate; BASIONICreg; BC 01 in water; acetonitrile T=30°C; 0.33 h;
参考文献
Zhao, Hua; Jackson, Lee; Song, Zhiyan; Olubajo, Olarongbe
Tetrahedron Asymmetry, 2006 , vol. 17, # 17 p. 2491 - 2498
反应条件
1: H2O; alcalase / 2-methyl-propan-2-ol / 2.5 h / 25 °C / pH 8.5 2: H2O / 2-methyl-propan-2-ol / pH 11.5 View Scheme
参考文献
Chen, Shui-Tein; Wang, Kung-Tsung
Journal of the Chinese Chemical Society, 1999 , vol. 46, # 3 p. 301 - 311
反应条件
Bacillus licheniformis protease; 5-aminopentanoic acid 1-ethyl-3-methylimidazolium salt; sodium hydrogencarbonate in water T=30°C; Product distribution; Further Variations:SolventsReagents;
参考文献
Zhao, Hua; Jackson, Lee; Song, Zhiyan; Olubajo, Olarongbe
Tetrahedron Asymmetry, 2006 , vol. 17, # 10 p. 1549 - 1553
