2-氰基-N-环己基-乙酰胺合成路线 （共 8 条）
反应条件
sodium ethanolate in ethanol T=20°C; 1 h;
参考文献
Cheikh, Nawel; Bar, Nathalie; Choukchou-Braham, Nourredine; Mostefa-Kara, Bachir; Lohier, Jean-Franois; Sopkova, Jana; Villemin, Didier
Tetrahedron, 2011 , vol. 67, # 8 p. 1540 - 1551
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in DCM T=18 - 25°C; 24 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/99145 A1, 2008 ;
Location in patent: Page/Page column 88 ;
WO 2008/099145 A1
反应条件
1-methyl-piperazine T=20°C; 4 h;
参考文献
Letters in Drug Design and Discovery, , vol. 11, # 1 p. 2 - 9
参考文献
Gazit, Aviv; Osherov, Nir; Posner, Israel; Yaish, Pnina; Poradosu, Enrique; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1896 - 1907
反应条件
1.1: EtONa / ethanol / 0.5 h 1.2: 78 percent / EtONO / 1 h / 0 °C 2.1: 48 percent / Al/Hg / ethanol / 4 h / 0 - 25 °C 3.1: 74 percent / 1N HCl; NaNO2 / H2O / 0 °C View Scheme
参考文献
Morzherin; Kolobov; Mokrushin; Brauer; Anders; Bakulev
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 1 p. 22 - 36
反应条件
1: With sodium ethanolate in ethanol
deprotonation; 0.5 h;
2: With EtO-NO
T=0°C; Condensation; 1 h;
参考文献
Morzherin; Kolobov; Mokrushin; Brauer; Anders; Bakulev
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 1 p. 22 - 36
反应条件
hydrogen sulfide; triethylamine in ethanol
T=70°C; 1.5 h;
参考文献
Morzherin; Kosterina; Berseneva; Dehaen; Bakulev
Russian Chemical Bulletin, 2002 , vol. 51, # 7 p. 1292 - 1297
反应条件
sodium acetate; acetic anhydride
1 h; Reflux;
参考文献
Helal, Mohamed H.; El-Hag Ali, Gameel A. M.; Ali, Ahmed A.; Ammar, Yousry A.
Journal of Chemical Research, 2010 , # 8 p. 465 - 469
