2-氰基-n-(2-羟基乙基)乙酰胺合成路线 （共 6 条）
反应条件
in ethanol 4 h; Heating / reflux;
参考文献
N.V. ORGANON
Patent: WO2008/3452 A1, 2008 ;
Location in patent: Page/Page column 72 ;
WO 2008/003452 A1
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; Taunton, JR., John William; Maglathlin, Rebecca; Serafimova, Iana; Cohen, Michael S.; Miller, Rand; Paavilainen, Ville; McFarland, Jesse; Krishnan, Shyam
Patent: US2013/35325 A1, 2013 ;
Location in patent: Paragraph 0393; 0394 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C; 3.08333 h;
参考文献
Zhou, Linna; Stewart, Gavin; Rideau, Emeline; Westwood, Nicholas J.; Smith, Terry K.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 796 - 806
反应条件
hydrogenchloride; potassium hydroxide 1) methanol, reflux, 6h, 2) ethanol; Yield given. Multistep reaction;
参考文献
Tilak, B. D.; Ayyangar, N. R.; Rao, U. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 18 - 23
反应条件
1: 1) potassium hydroxide, 2) 5percent hydrogen chloride / 1) methanol, reflux, 6h, 2) ethanol
2: 15 g / 3 h / 180 °C / 50 Torr / o-dichlorobenzene, Dean-Stark
View Scheme
参考文献
Tilak, B. D.; Ayyangar, N. R.; Rao, U. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 18 - 23
反应条件
1: 1) potassium hydroxide, 2) 5percent hydrogen chloride / 1) methanol, reflux, 6h, 2) ethanol
2: 15 g / 3 h / 180 °C / 50 Torr / o-dichlorobenzene, Dean-Stark
3: 1.4 g / 96percent sulphuric acid / 1 h / 80 °C
View Scheme
参考文献
Tilak, B. D.; Ayyangar, N. R.; Rao, U. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 1 p. 18 - 23
