N-苄氧羰酰基-2-甲基丙氨酸合成路线 （共 18 条）
反应条件
1.1: 4-methyl-morpholine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C 2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 4 h / -78 °C / Inert atmosphere View Scheme
参考文献
Jadhav, Sandip V.; Misra, Rajkumar; Singh, Sumeet K.; Gopi, Hosahudya N.
Chemistry - A European Journal, 2013 , vol. 19, # 48 p. 16256 - 16262
反应条件
1: With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 3 h; 2: With hydrogen; palladium 10 on activated carbon in methanol T=20°C;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1548024 A1, 2005 ;
Location in patent: Page/Page column 69 ;
反应条件
fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; pyridine in dichloromethane-d2
T=25°C; Kinetics;
参考文献
Fiammengo; Licini; Nicotra; Modena; Pasquato; Scrimin; Broxterman; Kaptein
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5905 - 5910
反应条件
camphor-10-sulfonic acid in toluene
1.5 h; Heating / reflux;
参考文献
UBIQUITOUS TECHNOLOGIES PTY LTD
Patent: WO2004/7427 A1, 2004 ;
Location in patent: Page 86 ;
反应条件
chloroform
und Behandeln des Reaktionsgemisches mit Glycin-aethylester und Hydrieren des durch alkalische Hydrolyse erhaltenen Reaktionsprodukts an Palladium in wenig Essigsaeure enthaltendem Methanol;
参考文献
Martin
Australian Journal of Chemistry, 1957 , vol. 10, p. 268,271
反应条件
(i) Et3N, ClCO2Et, (ii) /BRN= 635782/, aq. NaOH, (iii) H2, Pd; Multistep reaction;
参考文献
Faust,G.; Lang,H.
Journal fuer Praktische Chemie (Leipzig), 1960 , vol. 11, p. 153 - 164
反应条件
1: dicyclohexyl-carbodiimide / tetrahydrofuran / 1 h / 0 °C
2: sodium tetrahydroborate / water; tetrahydrofuran / 0.08 h / 0 °C
View Scheme
参考文献
Jadhav, Sandip V.; Misra, Rajkumar; Singh, Sumeet K.; Gopi, Hosahudya N.
Chemistry - A European Journal, 2013 , vol. 19, # 48 p. 16256 - 16262
反应条件
4-methyl-morpholine in tetrahydrofuran
30 h; Ambient temperature;
参考文献
Wipf, Peter; Heimgartner, Heinz
Helvetica Chimica Acta, 1988 , vol. 71, p. 140 - 154
