N-芴甲氧羰基-3-[[(4-甲氧基苯基)甲基]硒基]-L-丙氨酸合成路线 （共 9 条）
反应条件
triethylamine in water; acetonitrile
1 h; Ambient temperature;
参考文献
Koide; Itoh; Otaka; Yasui; Kuroda; Esaki; Soda; Fujii
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 3 p. 502 - 506
反应条件
morpholine; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
1 h;
参考文献
Gieselman, Matt D.; Xie, Lili; Van Der Donk, Wilfred A.
Organic Letters, 2001 , vol. 3, # 9 p. 1331 - 1334
反应条件
triethylamine in water; acetonitrile
T=20°C; 1 h;
参考文献
Hondal; Nilsson; Raines
Journal of the American Chemical Society, 2001 , vol. 123, # 21 p. 5140 - 5141
反应条件
1: 76 percent / aliquat-336; NaHCO3 / H2O; CH2Cl2 / 72 h
2: 94 percent / pyridine / 11 h / 0 °C
3: 5.29 g / NaOH / H2O; dimethylformamide; acetone / 4 h / 0 °C
4: 99 percent / morpholine / Pd(PPh3)4 / tetrahydrofuran / 1 h
View Scheme
参考文献
Gieselman, Matt D.; Xie, Lili; Van Der Donk, Wilfred A.
Organic Letters, 2001 , vol. 3, # 9 p. 1331 - 1334
反应条件
1: 84 percent / LiB(Et)3H; selenium / tetrahydrofuran / -78 - 20 °C
2: H3PO2 / tetrahydrofuran; H2O / 1 h / Heating
3: 5.29 g / NaOH / H2O; dimethylformamide; acetone / 4 h / 0 °C
4: 99 percent / morpholine / Pd(PPh3)4 / tetrahydrofuran / 1 h
View Scheme
参考文献
Gieselman, Matt D.; Xie, Lili; Van Der Donk, Wilfred A.
Organic Letters, 2001 , vol. 3, # 9 p. 1331 - 1334
反应条件
trimethyl tin hydroxide in 1,2-dichloro-ethane
1 h; Inert atmosphereReflux;
参考文献
Schroll, Alayne L.; Hondal, Robert J.; Flemer, Stevenson
Journal of Peptide Science, 2012 , vol. 18, # 3 p. 155 - 162
反应条件
1.1: pyridine / 7 h / 0 °C
2.1: lithium triethylborohydride / tetrahydrofuran / 0 °C / Inert atmosphere
2.2: 0 °C
3.1: trimethyl tin hydroxide / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux
View Scheme
参考文献
Schroll, Alayne L.; Hondal, Robert J.; Flemer, Stevenson
Journal of Peptide Science, 2012 , vol. 18, # 3 p. 155 - 162
反应条件
1.1: lithium triethylborohydride / tetrahydrofuran / 0 °C / Inert atmosphere
1.2: 0 °C
2.1: trimethyl tin hydroxide / 1,2-dichloro-ethane / 1 h / Inert atmosphere; Reflux
View Scheme
参考文献
Schroll, Alayne L.; Hondal, Robert J.; Flemer, Stevenson
Journal of Peptide Science, 2012 , vol. 18, # 3 p. 155 - 162
反应条件
1: thionyl chloride / chloroform / 2 h / 5 - 20 °C
2: sodium hydroxide / 4 h / 4 °C
3: triethylamine / acetonitrile; water / 1 h / 20 °C / pH > 8
View Scheme
参考文献
Adams, Anna L.; Macmillan, Derek
Journal of Peptide Science, 2013 , vol. 19, # 2 p. 65 - 73
