5-[2-环丙基-1-(2-氟苯基)-2-氧代乙基]-5,6,7,7a-四氢噻吩并[3,2-c]吡啶-2(4H)-酮合成路线 （共 28 条）
反应条件
1: With hydrogenchloride; water in ethyl acetate T=20°C; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
ammonium hydrogen carbonate in dichloromethane T=5 - 20°C;
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
sodium hydrogencarbonate in water T=10 - 15°C; 0.5 h;
参考文献
WO2011/42918 A2, ;
Page/Page column 47-48 ;
反应条件
sodium carbonate in N,N-dimethyl-formamide T=0 - 5°C; 3 h; Product distribution / selectivity;
参考文献
WO2009/66326 A2, ;
Page/Page column 19-20 ;
反应条件
1: With hydrogenchloride; water T=70°C; 5 h; 2: pH=10; Alkaline conditions;
参考文献
WO2011/110219 A1, ;
Page/Page column 17; 18 ;
反应条件
1: With hydrogenchloride; water T=90°C; 4 h; 2: pH=10; Alkaline conditions;
参考文献
WO2011/110219 A1, ;
Page/Page column 19 ;
反应条件
1.1: toluene-4-sulfonic acid; 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chloroform / 4 h / Reflux 2.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 3.2: 1 h / -78 °C 3.3: 1 h / -60 - 0 °C View Scheme
反应条件
triethylamine in tetrahydrofuran T=0 - 5°C; 3 h; Product distribution / selectivity;
参考文献
WO2009/66326 A2, ;
Page/Page column 21 ;
反应条件
1.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 1.2: 40 - 50 °C 1.3: 0.25 h / 0 - 30 °C 2.1: toluene-4-sulfonic acid; 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chloroform / 4 h / Reflux 3.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 4.2: 1 h / -78 °C 4.3: 1 h / -60 - 0 °C View Scheme
反应条件
sodium carbonate in tetrahydrofuran T=0 - 5°C; 5 h; Product distribution / selectivity;
参考文献
WO2009/66326 A2, ;
Page/Page column 16 ;
