5-[2-环丙基-1-(2-氟苯基)-2-氧代乙基]-5,6,7,7a-四氢噻吩并[3,2-c]吡啶-2(4H)-酮合成路线 （共 28 条）
反应条件
1.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 2.2: 1 h / -78 °C 2.3: 1 h / -60 - 0 °C View Scheme
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C / Inert atmosphere 1.3: 2 h / 0 - 30 °C 2.1: acetone / 0.42 h / 25 - 30 °C 3.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 3.2: 7 h / 25 - 30 °C 3.3: 8 h / 0 - 25 °C 4.1: sodium hydrogencarbonate / water / 0.5 h / 10 - 15 °C View Scheme
反应条件
1.1: acetone / 0.42 h / 25 - 30 °C 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 2.3: 8 h / 0 - 25 °C 3.1: sodium hydrogencarbonate / water / 0.5 h / 10 - 15 °C View Scheme
反应条件
1.1: triethylamine / dichloromethane / 0.25 h / 0 - 5 °C 1.2: 6 h / 0 - 5 °C 2.1: iodine; magnesium / tetrahydrofuran / 25 - 50 °C 2.2: 40 - 50 °C 2.3: 0.25 h / 0 - 30 °C 3.1: toluene-4-sulfonic acid; 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chloroform / 4 h / Reflux 4.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 5.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 5.2: 1 h / -78 °C 5.3: 1 h / -60 - 0 °C View Scheme
反应条件
1.1: potassium carbonate / acetonitrile / 5 h / 25 - 35 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 2.2: 1 h / -78 °C 2.3: 1 h / -60 - 0 °C View Scheme
反应条件
1.1: tetrabutylammomium bromide / dichloromethane; water / 25 °C 2.1: sodium hydroxide; water / 5 - 95 °C 2.2: pH 2 - 3 3.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 3.2: 5 - 65 °C 4.1: dibenzoyl peroxide; N-bromosuccinmide / ethyl acetate / 25 - 60 °C 5.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 6.1: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme
反应条件
1.1: sodium hydroxide; water / 5 - 95 °C 1.2: pH 2 - 3 2.1: magnesium; isopropyl bromide / toluene; tetrahydrofuran / 15 - 65 °C 2.2: 5 - 65 °C 3.1: dibenzoyl peroxide; N-bromosuccinmide / ethyl acetate / 25 - 60 °C 4.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 5.1: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme
反应条件
1.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 1.2: 7 h / 25 - 30 °C 1.3: 8 h / 0 - 25 °C 2.1: sodium hydrogencarbonate / water / 0.5 h / 10 - 15 °C View Scheme
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C 4.1: tetrahydrofuran / 25 °C 5.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 6.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 7.1: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme
反应条件
1.1: potassium phosphate; copper; copper(l) iodide / 2-(dimethylamino)-ethanol / 24 h / 80 °C 2.1: hydrogenchloride / diethyl ether / Cooling with ice 3.1: triethylamine / acetonitrile / Cooling with ice 4.1: hydrogenchloride; water / 5 h / 70 °C 4.2: pH 10 / Alkaline conditions View Scheme
