5-[2-环丙基-1-(2-氟苯基)-2-氧代乙基]-5,6,7,7a-四氢噻吩并[3,2-c]吡啶-2(4H)-酮合成路线 (共 28 条)
反应条件
1.1: triethylamine / acetonitrile / Cooling with ice 2.1: hydrogenchloride; water / 5 h / 70 °C 2.2: pH 10 / Alkaline conditions View Scheme
反应条件
1.1: triethylamine / dichloromethane / 5 h / 20 °C 2.1: hydrogenchloride; water / 4 h / 90 °C 2.2: pH 10 / Alkaline conditions View Scheme
反应条件
1.1: hydrogenchloride / diethyl ether / Cooling with ice 2.1: triethylamine / acetonitrile / Cooling with ice 3.1: hydrogenchloride; water / 5 h / 70 °C 3.2: pH 10 / Alkaline conditions View Scheme
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 20 °C / Inert atmosphere 3: hydrogenchloride; water / ethyl acetate / 20 °C View Scheme
反应条件
acetic anhydride in N-methyl-acetamide; mineral oil
反应条件
1: With acetic acid in toluene T=20°C; Inert atmosphere; 2: With sodium hydrogencarbonate in water; toluene
参考文献
WO2012/1486 A1, ;
Page/Page column 23 ;
反应条件
triethylamine in dichloromethane T=25°C; 1 h; Solvent;
参考文献
WO2013/14295 A1, ;
Page/Page column 23 ;
反应条件
toluene-4-sulfonic acid T=65 - 70°C; 3.5 h;
参考文献
WO2013/14295 A1, ;
Page/Page column 23-24 ;