1-环丙基-2-(2-氟苯基)乙酮合成路线 （共 19 条）
反应条件
1: 2-fluoro-benzyl bromide With magnesium; methyl iodide in diethyl ether T=20°C; 2: cyclopropanecarbonitrile in diethyl ether T=20°C; 3: With water; ammonium chloride in diethyl ether T=0°C; Product distribution / selectivity;
参考文献
TORRENT PHARMACEUTICALS LTD.
Patent: WO2009/122440 A1, 2009 ;
Location in patent: Page/Page column 31 ;
反应条件
1: cyclopropyl bromide With iodine; magnesium in tetrahydrofuran T=25 - 50°C; 2: 2-(2-fluorophenyl)-N-methoxy-N-methylacetamide in tetrahydrofuran T=40 - 50°C; 3: With hydrogenchloride in tetrahydrofuran; water T=0 - 30°C; 0.25 h;
参考文献
WO2011/42918 A2, ;
Page/Page column 49-50 ;
反应条件
1: 2-fluoro-benzyl bromide With magnesium in diethyl ether T=20°C; 1 h; 2: cyclopropanecarbonitrile in diethyl ether T=20°C; 3.16667 h; Heating / reflux;
参考文献
US2007/243243 A1, ;
Page/Page column 20 ;
反应条件
1: 2-(2-fluorophenyl)acetic acid With magnesium; isopropyl bromide in tetrahydrofuran; toluene T=15 - 65°C; 2: cyclopropanecarboxylic acid methyl ester in tetrahydrofuran; toluene T=5 - 65°C;
参考文献
WO2012/1486 A1, ;
Page/Page column 16 ;
反应条件
1: 2-(2-fluorophenyl)acetic acid With magnesium; isopropyl bromide in tetrahydrofuran; toluene T=15 - 65°C; 2: cyclopropanecarboxylic acid ethyl ester in tetrahydrofuran; toluene T=5 - 65°C;
参考文献
WO2012/1486 A1, ;
Page/Page column 16 ;
反应条件
1: 1-(chloromethyl)-2-fluorobenzene With iodine; magnesium in diethyl ether 2 h; Heating / reflux; 2: cyclopropanecarboxylic acid dimethylamide in tetrahydrofuran; diethyl ether 0.5 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR Nyilvanosan Mkoed Reszvenytarsasag
Patent: WO2009/68923 A2, 2009 ;
Location in patent: Page/Page column 9-10 ;
反应条件
1: 1-(chloromethyl)-2-fluorobenzene With iodine; magnesium in diethyl ether 2 h; Heating / reflux; 2: cyclopropanecarboxylic acid diethylamide in tetrahydrofuran; diethyl ether 0.5 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR Nyilvanosan Mkoed Reszvenytarsasag
Patent: WO2009/68923 A2, 2009 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: 1-(chloromethyl)-2-fluorobenzene With iodine; magnesium in diethyl ether 2 h; Heating / reflux; 2: cyclopropanecarbonitrile in tetrahydrofuran; diethyl ether T=-50°C; 0.5 h; Heating / reflux; 3: With hydrogenchloride; water Product distribution / selectivity;
参考文献
WO2009/68923 A2, ;
Page/Page column 14 ;
反应条件
1: 1-(chloromethyl)-2-fluorobenzene With iodine; magnesium in diethyl ether 2 h; Heating / reflux; 2: cyclopropanecarboxylic acid diisopropylamide in tetrahydrofuran; diethyl ether 2 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR Nyilvanosan Mkoed Reszvenytarsasag
Patent: WO2009/68923 A2, 2009 ;
Location in patent: Page/Page column 11 ;
