4-叔丁氧羰基-2(S)-哌嗪叔丁酰胺合成路线 （共 2 条）
反应条件
1: 83 percent / (i-Pr)2NEt / propan-2-ol / 3.5 h 2: aq. LiOH / 1,2-dimethoxy-ethane / 0.5 h 3: imidazole / 1,2-dimethoxy-ethane / 20 h / 0 - 20 °C 4: 92 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBt, Et3N / dimethylformamide / 18 h / 0 - 20 °C 5: 69 percent / 8N HCl / propan-2-ol / 6 h / Ambient temperature View Scheme
参考文献
Askin, David; Eng, Kan K.; Rossen, Kai; Purick, Robert M.; Wells, Kenneth M.; et al.
Tetrahedron Letters, 1994 , vol. 35, # 5 p. 673 - 676
反应条件
1: 83 percent / (i-Pr)2NEt / propan-2-ol / 3.5 h 2: aq. LiOH / 1,2-dimethoxy-ethane / 0.5 h 3: imidazole / 1,2-dimethoxy-ethane / 20 h / 0 - 20 °C 4: 92 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBt, Et3N / dimethylformamide / 18 h / 0 - 20 °C 5: 69 percent / 8N HCl / propan-2-ol / 6 h / Ambient temperature 6: 76 percent / Et3N / dimethylformamide / 12 h View Scheme
参考文献
Askin, David; Eng, Kan K.; Rossen, Kai; Purick, Robert M.; Wells, Kenneth M.; et al.
Tetrahedron Letters, 1994 , vol. 35, # 5 p. 673 - 676
