[1(1S,2R),5(S)]-2,3,5-三脱氧-N-(2,3-二氢-2-羟基-1H-茚-1-基)-5-[2-[(叔丁基氨基)甲酰]-1-哌嗪基]-2-(苯基甲基)-D-赤式-戊酰胺合成路线 （共 25 条）
反应条件
1: aq. LiOH / 1,2-dimethoxy-ethane / 0.5 h 2: imidazole / 1,2-dimethoxy-ethane / 20 h / 0 - 20 °C 3: 92 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBt, Et3N / dimethylformamide / 18 h / 0 - 20 °C 4: 69 percent / 8N HCl / propan-2-ol / 6 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 21 p. 3443 - 3451
反应条件
1: imidazole / 1,2-dimethoxy-ethane / 20 h / 0 - 20 °C 2: 92 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBt, Et3N / dimethylformamide / 18 h / 0 - 20 °C 3: 69 percent / 8N HCl / propan-2-ol / 6 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 21 p. 3443 - 3451
反应条件
1: 92 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBt, Et3N / dimethylformamide / 18 h / 0 - 20 °C 2: 69 percent / 8N HCl / propan-2-ol / 6 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 21 p. 3443 - 3451
反应条件
1: (COCl)2 3: 1.) H2; 2.) (S)-camphorsulphonic acid (CSA) / 1.) Pd(OH)2/C 4: Et3N 5: IPA / Heating 6: 6N HCl View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 5 p. 673 - 676
反应条件
2: 1.) H2; 2.) (S)-camphorsulphonic acid (CSA) / 1.) Pd(OH)2/C 3: Et3N 4: IPA / Heating 5: 6N HCl View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 5 p. 673 - 676
反应条件
1: 1.) H2; 2.) (S)-camphorsulphonic acid (CSA) / 1.) Pd(OH)2/C 2: Et3N 3: IPA / Heating 4: 6N HCl View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 5 p. 673 - 676
反应条件
1: 1.) n-BuLi / 2.) -30 deg C 2: t-amylOK 3: IPA / Heating 4: 6N HCl View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 5 p. 673 - 676
参考文献
Tetrahedron Letters, , vol. 35, # 5 p. 673 - 676
反应条件
1: 20 percent 2: 6N HCl View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 5 p. 673 - 676
反应条件
1: peracid 2: IPA / Heating 3: 6N HCl View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 5 p. 673 - 676
