3-(N-Boc-N-甲氨基)丙胺合成路线 （共 5 条）
反应条件
in tetrahydrofuran T=0 - 20°C; 18 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; BALOGLU, Erkan
Patent: WO2013/6408 A1, 2013 ;
Location in patent: Page/Page column 40 ;
反应条件
hydrazine hydrate in methanol T=60°C; 4.5 h; Reflux;
参考文献
Li, Hongbo; Hao, Meng-An; Wang, Liping; Liang, Wu; Chen, Kai
Organic Preparations and Procedures International, 2009 , vol. 41, # 4 p. 301 - 307
反应条件
hydrogenchloride in methanol T=0 - 20°C; 3 h;
参考文献
Choi, Doo Li; Jang, Sun Jeong; Cho, Sehyeon; Choi, Hye-Eun; Rim, Hong-Kun; Lee, Kyung-Tae; Lee, Jae Yeol
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1565 - 1570
反应条件
1: tetrahydrofuran / 0 °C 2: OH- / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 5 p. 855 - 858
反应条件
1: With sodium hydride 2: With hydrazine
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 13 p. 4312 - 4331
