3-苯基-2-丙炔-1-醇合成路线 （共 165 条）
反应条件
1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 3 h / 0 °C / |Darkness
2: diethylzinc; oxygen / dichloromethane; n-heptane / 14 h / 20 °C / |Darkness
View Scheme
参考文献
Jammi, Suribabu; Mouysset, Dominique; Siri, Didier; Bertrand, Michele P.; Feray, Laurence
Journal of Organic Chemistry, 2013 , vol. 78, # 4 p. 1589 - 1603
反应条件
hydrogen; triphenylphosphine; dirhodium tetraacetate in dichloromethane
T=65°C; P=36200.4 Torr; 24 h; Product distribution; Further Variations:ReagentsSolventsTemperaturescatalyst/ligand ratio;
参考文献
Nanayakkara, Peru; Alper, Howard
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 4-5 p. 545 - 550
反应条件
sodium hydride in tetrahydrofuran; mineral oil
参考文献
Xie, Yongju; Yu, Ming; Zhang, Yuhong
Synthesis, 2011 , # 17 art. no. H48311SS, p. 2803 - 2809
反应条件
sodium hydroxide
2 h; Heating;
参考文献
Jackson, W. Roy; Perlmutter, Patrick; Smallridge, Andrew J.
Australian Journal of Chemistry, 1988 , vol. 41, # 2 p. 251 - 261
反应条件
manganese(IV) oxide; ammonia; magnesium sulfate in tetrahydrofuran; isopropyl alcohol
T=20°C; 24 h;
参考文献
McAllister, Graeme D.; Wilfred, Cecilia D.; Taylor, Richard J. K.
Synlett, 2002 , # 8 p. 1291 - 1292
反应条件
1: phosphorus tribromide / 0.5 h / 0 °C
2: potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux
View Scheme
参考文献
Padwa, Albert; Meske, Michael; Ni, Zhijie
Tetrahedron, 1995 , vol. 51, # 1 p. 89 - 106
反应条件
1: sodium acetate / 125 °C
2: mercury (II)-acetate; aqueous acetic acid
View Scheme
参考文献
Wenus-Danilowa; Danilow
Zhurnal Obshchei Khimii, 1932 , vol. 2, p. 645,652, 653
Chem. Zentralbl., C 1933 II 47
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
T=0°C; 3 h; Darkness;
参考文献
Jammi, Suribabu; Mouysset, Dominique; Siri, Didier; Bertrand, Michele P.; Feray, Laurence
Journal of Organic Chemistry, 2013 , vol. 78, # 4 p. 1589 - 1603
反应条件
1: triethylamine / dichloromethane
2: lithium bromide / tetrahydrofuran; dichloromethane
3: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwave irradiation
View Scheme
参考文献
Castagnolo, Daniele; Pagano, Mafalda; Bernardini, Martina; Botta, Maurizio
Synlett, 2009 , # 13 p. 2093 - 2096
反应条件
phthalimide; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine
1.) THF, RT, 3 d, 2.) THF, reflux; Yield given. Multistep reaction;
参考文献
Moody, Christopher J.; Rahimtoola, Kulsum F.; Porter, Barry; Ross, Barry C.
Journal of Organic Chemistry, 1992 , vol. 57, # 7 p. 2105 - 2114
