trifluoroacetic acid in dichloromethane T=20°C; 20 h;

1: (E)-1-(benzylthio)-1-propene With ammonia; sodium in diethyl ether T=-42°C; 2: β-chloro-L-alanine hydrochloride in tetrahydrofuran T=0 - 20°C; 18 h; 3: With acetic acid in tetrahydrofuran; water pH=5 - 6;

ammonia; sodium Yield given. Multistep reaction;

1: 94 percent / LiOH / methanol / 12 h / 4 °C 2: 78 percent / trifluoroacetic acid / CH2Cl2 / 20 h / 20 °C View Scheme