反应条件
1: 3-(4-methylphenyl)propanoic acid With 1,1'-carbonyldiimidazole in dichloromethane
T=20°C; 1.91667 h;
2: methylamine in dichloromethane; water
T=0 - 20°C;
3: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 60°C; 6 h; Further stages.;
参考文献
Henke, Brad R.; Consler, Thomas G.; Go, Ning; Hale, Ron L.; Hohman, Dana R.; Jones, Stacey A.; Lu, Amy T.; Moore, Linda B.; Moore, John T.; Orband-Miller, Lisa A.; Robinett, R. Graham; Shearin, Jean; Spearing, Paul K.; Stewart, Eugene L.; Turnbull, Philip S.; Weaver, Susan L.; Williams, Shawn P.; Wisely, G. Bruce; Lambert, Millard H.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5492 - 5505
