5-甲基-1-苯并噻吩-2-羧酸合成路线 （共 7 条）
反应条件
sodium hydroxide in tetrahydrofuran; methanol; water 0.333333 h; Heating / reflux;
参考文献
US2004/10004 A1, ;
Page 22 ;
反应条件
1: 5-methyl-benzo[b]thiophene With n-butyllithium in diethyl ether; hexane T=-10°C; 1 h; 2: carbon dioxide in diethyl ether; hexane T=-10°C; 3: With hydrogenchloride in diethyl ether; hexane; water
参考文献
US2003/199571 A1, ;
Page/Page column 8 ;
反应条件
sodium hydroxide; bromine in 1,4-dioxane; water
参考文献
US5350751 A1, ;
US 5350751 A
反应条件
chloroacetic acid T=100°C;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 566, p. 139,145
参考文献
Tsuchiya, Naoki; Matsumoto, Yoshiyuki; Saitou, Hiroshi; Mizuno, Tsuyoshi
Patent: US2004/10004 A1, 2004 ;
Location in patent: Page 23 ;
参考文献
Pfizer Inc.
Patent: US4410539 A1, 1983 ;
反应条件
hydrogenchloride
3 h; Heating;
参考文献
Cross; Dickinson; Parry; Randall
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1637 - 1643
