(2R)-(4-溴苯基)(羟基)乙腈合成路线 (共 7 条)
反应条件
citrate-phosphate buffer; Arabidopsis thaliana hydroxynitrile lyase in di-isopropyl ether T=10°C; pH=5.0; 3 h;
参考文献
Andexer, Jennifer; Von Langermann, Jan; Mell, Annett; Bocola, Marco; Kragl, Udo; Eggert, Thorsten; Pohl, Martina
Angewandte Chemie - International Edition, 2007 , vol. 46, # 45 p. 8679 - 8681
反应条件
hydrogenchloride; water in ethyl acetate T=20°C; 12 h;
参考文献
Blocka, Ewelina; Bosiak, Mariusz J.; Welniak, Miroslaw; Ludwiczak, Agnieszka; Wojtczak, Andrzej
Tetrahedron Asymmetry, 2014 , vol. 25, # 6-7 p. 554 - 562
反应条件
1: 4-bromo-benzaldehyde With (1R,2R)-cyclohexane-1,2-diylbis(2-azaethenyl-3-tert-butyl-2-hydroxybenzo-5-sulfonic acid) disodium salt; Manganese (II) acetate in methanol T=20°C; 0.5 h; 2: sodium cyanide in methanol T=20°C; 24 h; optical yield given as percent eeenantioselective reaction;
参考文献
Qu, Yanyang; Jing, Linhai; Wu, Zhiqing; Wu, Di; Zhou, Xiangge
Tetrahedron Asymmetry, 2010 , vol. 21, # 2 p. 187 - 190
反应条件
in di-isopropyl ether T=5°C; 48 h; almond meal oxynitrilase, 0.1 M tartrate buffer, pH 5.4;
参考文献
Kiljunen, Eero; Kanerva, Liisa T.
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1105 - 1116
反应条件
Prunus mume (R)-hydroxynitrile lyase; citrate buffer in di-isopropyl ether pH=4.0; 26 h;
参考文献
Nanda, Samik; Kato, Yasuo; Asano, Yasuhisa
Tetrahedron, 2005 , vol. 61, # 46 p. 10908 - 10916
反应条件
lipase PS-30 in diethyl ether T=15°C; 39.5 h; Molecular sieveResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Xu, Qing; Xie, Yongli; Geng, Xiaohong; Chen, Peiran
Tetrahedron, 2010 , vol. 66, # 3 p. 624 - 630
反应条件
acetic acid in methanol 4 h; Prunnus capuli defatted meal, citrate buffer (pH 4.0); Title compound not separated from byproducts;
参考文献
Solis, Aida; Luna, Hector; Perez, Herminia I.; Manjarrez, Norberto; Sanchez, Remedios; Gutierrez, Atilano
Tetrahedron Letters, 1998 , vol. 39, # 48 p. 8759 - 8762