(S)-2-甲酰基-1-哌啶甲酸叔丁酯合成路线 （共 23 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine in dichloromethane T=-78 - 20°C; Oxidation;
参考文献
Singh, Ritesh; Panda, Gautam
RSC Advances, 2013 , vol. 3, # 42 p. 19533 - 19544
反应条件
lithium aluminium tetrahydride in diethyl ether T=0 - 20°C; 0.5 h;
参考文献
Tong, Sok Teng (Amy); Barker, David
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5017 - 5020
反应条件
1: 60 percent / DIBAL-H / -78 °C View Scheme
参考文献
Synlett, , # 3 p. 435 - 439
反应条件
diisobutylaluminium hydride in toluene T=-78°C; 0.666667 h; Inert atmosphere;
参考文献
Zhou, Gang; Liu, Xian; Liu, Xueying; Nie, Huifang; Zhang, Shengyong; Chen, Weiping
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3575 - 3580
反应条件
1: NaHCO3 / methanol 2: 60 percent / DIBAL-H / -78 °C View Scheme
参考文献
Synlett, , # 3 p. 435 - 439
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 6.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 7.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 6.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 7.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 89 percent / NaH / tetrahydrofuran / 6 h / 20 °C 2.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 5 h / -78 °C 2.2: 80 percent / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C 3.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 4.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 5.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 1.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 2.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 3.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 4.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 86 percent / p-TsOH / toluene / 0.33 h 2.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 2.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 3.1: 87 percent / H2 / (S)-BINAP; RuCl2 / methanol / 11 h / 45 °C / 51716.2 Torr 4.1: 97 percent / BH3*THF / tetrahydrofuran / 3 h / 20 °C 5.1: 98 percent / oxalyl chloride; DMSO; DIPEA / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
