2-(3-溴苯基)乙酸甲酯合成路线 （共 29 条）
反应条件
hydrogenchloride 1 h; Heating;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1479681 A1, 2004 ;
Location in patent: Page 111; 112 ;
反应条件
sulfuric acid in methanol 3 h; Heating / reflux;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; AstraZeneca AB
Patent: EP1939202 A1, 2008 ;
Location in patent: Page/Page column 41 ;
反应条件
in methanol; toluene
参考文献
Bigge, Christopher Franklin; Bridges, Alexander James; Casimiro-Garcia, Agustin; Fakhoury, Stephen Alan; Lee, Helen Tsenwhei; Reed, Jessica; Schaum, Robert; Schlosser, Kevin Matthew; Sexton, Karen; Zhou, Hairong
Patent: US2003/171377 A1, 2003 ;
反应条件
in methanol T=0 - 20°C; 5 h;
参考文献
EP1477167 A1, ;
Page/Page column 43 ;
EP 1477167 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 12 h; Inert atmosphere;
参考文献
Kambe, Tohru; Maruyama, Toru; Nakano, Masayuki; Yamaura, Yoshiyuki; Shono, Tomoyuki; Seki, Akiteru; Sakata, Kiyoto; Maruyama, Takayuki; Nakai, Hisao; Toda, Masaaki
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 12 p. 1523 - 1534
反应条件
in methanol; tert-butyl methyl ether
反应条件
in methanol T=-20°C; 3 h; Yield given;
参考文献
Helvetica Chimica Acta, , vol. 81, # 2 p. 251 - 267
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 2 p. 548 - 551
反应条件
tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide) T=90°C; 2 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1479681 A1, 2004 ;
Location in patent: Page 112 ;
