in N,N-dimethyl-formamide 18 h; Reflux;

暂无反应条件数据

sulfuric acid; nitric acid T=0 - 20°C; 4 h;

1.1: N,N-dimethyl-formamide / 18 h / |Reflux 2.1: sodium hydroxide / methanol / 16 h / 90 °C 2.2: pH Ca.3 View Scheme

1: 29 percent / H2SO4; HNO3 / 4 h / 0 - 20 °C 2: 69 percent / iron; NaOAc*3H2O; acetic acid / methanol; H2O / 1 h / 110 °C View Scheme

1: 2-(3-Bromo-phenyl)-acetic acid methyl ester With sodium hydride in tetrahydrofuran; mineral oil T=50°C; 2 h; Inert atmosphere; 2: methyl iodide in tetrahydrofuran; mineral oil T=20 - 40°C;

1: sodium hexamethyldisilazide / tetrahydrofuran / -78 - 20 °C 2: Me2AlCl / 20 °C 3: tetrahydrofuran / 2 h / 0 °C 4: LiBH(sec-Bu)3 / tetrahydrofuran / 0.5 h / 0 °C 5: Et3N / ethyl acetate / 0.5 h / 0 °C 6: NaN3 / dimethylformamide / 1 h / 120 °C 7: H2 / PtO2 / ethyl acetate / 24 h 8: tris(dibenzylideneacetone)dipalladium chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide; H2O / 24 h / 120 °C 9: HCl / ethyl acetate / 0.5 h / 20 °C 10: N-methylmorpholine; PyBOP / CH2Cl2 / 20 °C View Scheme

1: dimethylformamide / Heating 2: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 3: Et3N / tetrahydrofuran / 25 °C 4: aq. LiOH / tetrahydrofuran / 25 °C View Scheme

diisobutylaluminium hydride in dichloromethane; toluene T=-78°C; 0.666667 h;

1: dimethylformamide / Heating 2: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 3: Et3N / tetrahydrofuran / 25 °C View Scheme