1-苄基-1H-吡唑-4-羧酸乙酯合成路线 （共 5 条）
反应条件
1: 1H-pyrazole-4-carboxylic acid ethyl ester With sodium hydride in tetrahydrofuran T=20°C; 0.8 h; 2: benzyl bromide in tetrahydrofuran 2 h; 3: With water; ammonium chloride in tetrahydrofuran
参考文献
SEPRACOR INC.
Patent: US2008/4327 A1, 2008 ;
Location in patent: Page/Page column 75 ;
反应条件
potassium carbonate in acetone T=50°C; 16 h;
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US5389666 A1, 1995 ;
反应条件
potassium carbonate in acetone Heating;
参考文献
Elzein, Elfatih; Kalla, Rao; Li, Xiaofen; Perry, Thao; Parkhill, Eric; Palle, Venkata; Varkhedkar, Vaibahv; Gimbel, Art; Zeng, Dewan; Lustig, David; Leung, Kwan; Zablocki, Jeff
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 302 - 306
反应条件
potassium hydroxide in methanol Heating;
参考文献
Bailly, Jacques; Hertel, Cornelia; Hunziker, Daniel; Lerner, Christian; Obst Sander, Ulrike; Peters, Jens-Uwe; Pflieger, Philippe; Schulz-Gasch, Tanja
Patent: US2009/88425 A1, 2009 ;
Location in patent: Page/Page column 26 ;
US 20090088425 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; 1.58333 h;
2: With hydrogenchloride; water in tetrahydrofuran
参考文献
SEPRACOR INC.
Patent: US2008/4327 A1, 2008 ;
Location in patent: Page/Page column 75-76 ;
